人事人才

第23期 武漢光電青年論壇:膠原蛋白無創交聯機理、檢測及應用

來源:武漢光電國家研究中心    作者:    發布時間:2019年07月02日    浏覽:301次


時     間:2019年7月5日 9:30-11:00

地     點:光電國家研究中心 A301

報  告 人:王超, 哥倫比亞大學/哥倫比亞大學/哥倫比亞大學醫學部眼科中心

邀  請 人:曹祥東 博士


報告題目(Title):

Collagen noninvasive crosslinking mechanism, characterization and applications

膠原蛋白無創交聯機理、檢測及應用


報告摘要 (Abstract):

       近視眼在過去的50年裡有着急劇增長的患病率。目前患病率在歐美國家大約為50年前的兩倍;在東亞地區國家更為嚴重。作為一種常見的眼科流行病,眼鏡和隐形眼鏡仍然是主要對抗手段。随着科技的發展,哥倫比亞大學醫學中心Steven Trokel教授團隊率先提出了激光屈光矯正手術。然而,該手術會對角膜自然形态和生理條件造成永久性破壞,同時也會伴随許多術後副作用。基于激光-角膜接觸反應的新模型,我們提出了一種新型無創激光屈光矯正技術。其主要原理是通過低密度等離子激發活性氧基團,所産生的活性氧基團随之與鄰近的蛋白質發生反應,産生新的交聯。所引發的交聯會對角膜組織内部膠原蛋白重塑,并改善其生物力學性能。通過離體豬眼模型和活體兔模型,我們成功改變了角膜的屈光特性,進而對視力進行了改善。此外,基于我此前通過拉曼光譜檢測早期骨關節炎檢測的技術,我們将上述交聯模型運用到了早期骨關節炎治療中,為廣大患者帶來了福音。

The prevalence of myopia has increased worldwide over the last 50 years. Its incidence in the United States and Europe is now almost twice that 50 years ago, and it is even more prevalent in East Asia. Spectacles and contact lenses remain the most common means of vision correction, but the permanent correction of refractive errors, by refractive surgery, has emerged as an attractive alternative. However, such surgery is an invasive procedure that may compromise corneal structure, and post-surgical complications have been reported. We propose a novel, non-invasive approach to permanent vision correction based on a different mode of laser–cornea interaction. Our approach induces the formation of a low-density plasma that produces reactive oxygen species, which react with the surrounding proteins, forming crosslinks and triggering spatially resolved changes in mechanical properties. We show that the proposed method changes the refractive power of the eye, and confirm its safety and stability. Furthermore, together with the research of Raman characterization of early stage osteoarthritis, the proposed novel technique was also applied to provide new treatment options.



報告人簡介(Biography):

       王超,哥倫比亞大學/哥倫比亞大學醫學部眼科中心在讀博士、ResearchAssistant。主要研究方向為膠原蛋白光子交聯法機理研究、檢測及其相關應用。其無創膠原蛋白交聯方法應用目前主要包括無創屈光矯正等。相關科研成果以封面文章發表在《自然·光子學》中。

Chaois currently a PhD candidate in Columbia University and Columbia University Medical Center's Eye Institute. His research interest is novel noninvasive collagen crosslinking mechanism, characterization and applications. One of the most important applications is noninvasive vision correction, and this work has been published as cover article on Nature Photonics.